Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement.

@article{Vadia2012StudyOF,
  title={Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement.},
  author={Nasir Vadia and Sadhana J. Rajput},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2012},
  volume={45 1-2},
  pages={8-18}
}
The aim of this study was to develop methotrexate loaded mesoporous MCM-41 nanoparticles for improved dissolution of methotrexate. The mesoporous MCM-41 nanoparticles act as carrier for drug and increase the solubility of the drug. In order to achieve this objective small pore size MCM-41 nanoparticles have been synthesized followed by drug loading process. The process of drug loading was optimized using full 3³ factorial design. With a view to obtain maximum drug loading three variables… CONTINUE READING

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