Corpus ID: 100665025

Study on Purification Condition of Recombinant Human Manganese Superoxide Dismutase

@article{Qinsheng2007StudyOP,
  title={Study on Purification Condition of Recombinant Human Manganese Superoxide Dismutase},
  author={Yuan Qin-sheng},
  journal={Food and Drug},
  year={2007}
}
Objective To study the purification method of recombinant human manganese superoxide dismutase(rhMn-SOD).Methods The cells were fragmented by ultrasonic.The protein was precipitated by the thermal denaturation.The condition of proteins separation by DEAE ion exchange chromatography was optimized,then Sephadex G-100 molecular sieving was used to purify protein.Results The optimization condition of ultrasonic power was 300 W,the cycles of ultrasonic were 70 cycles,the best thermal denaturation… Expand
Enhanced anti-tumor effects achieved in a murine tumor model using combination therapy of recombinant human manganese superoxide dismutase and adriamycin.
TLDR
Data indicate that rhMnSOD may exhibit an anti-tumor effect by stimulating the immune system and promoting the recruitment of lymphocytes into the tumor to kill tumor cells, and may constitute a potential new therapeutic agent to be exploited as an adjuvant in cancer therapy. Expand