• Corpus ID: 87378569

Study on Immunity of Recombinant Vaccinia Viruses Containing env Gene of EIAV

@article{Chunming2003StudyOI,
  title={Study on Immunity of Recombinant Vaccinia Viruses Containing env Gene of EIAV},
  author={Dai Chunming and Zhang Xiao-yan and Shao Yi-ming and Shen Rong-xian},
  journal={Virologica Sinica},
  year={2003},
  volume={18},
  pages={473-477}
}
In order to develop new vaccine candidate of Equine infectious anema virus(EIAV),env gene of EIAV Chinese donkey leukocyte attenuated strain and its parental virus strain was inserted into the downstream of pE/L promoter of pSC65 vector,separately.The resulted recombinant vaccinia viruses were screened out by homologous recombination in TK region and the positive clone was confirmed with blue plaque assay.Protein expression was examined by W estern blot.It was shown that the recombinant… 
1 Citations
A conservative domain shared by HIV gp120 and EIAV gp90: implications for HIV vaccine design.
TLDR
V3 and V4 of EIAV gp90 are very similar to V1 and V2 of HIV gp120 and their glycosylation properties should be the regions preferably considered for HIV vaccine design.