Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by Microdialysis

@article{Deguchi1995StudyOB,
  title={Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by Microdialysis},
  author={Y. Deguchi and Kazimori Inabe and Koichi Tomiyasu and Kenji Nozawa and Shizuo Yamada and Ryohei Kimura},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={1838-1844}
}
Purpose. This study was performed to examine the distribution in the brain interstitial fluid (ISF) and the blood-brain barrier (BBB) transport of baclofen in rats by a microdialysis technique. Methods. Following an i.v. bolus administration and/or the constant i.v. infusion of baclofen to the microdialysis cannula-bearing anesthetized rats, the concentrations of baclofen in the hippocampal ISF, whole brain tissue, cerebrospinal fluid (CSF), and plasma were determined by high-performance liquid… CONTINUE READING
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