Study of viral integration of HPV-16 in young patients with LSIL.

  title={Study of viral integration of HPV-16 in young patients with LSIL.},
  author={Gianluca Gallo and Marluce Bibbo and L Bagella and Alessandra Zamparelli and Francesca Sanseverino and Maria Rosaria Giovagnoli and Aldo Vecchione and Antonio Giordano},
  journal={Journal of clinical pathology},
  volume={56 7},
AIMS To investigate the physical status of human papillomavirus 16 (HPV-16) in low grade squamous intraepithelial lesions (LSILs) as a means of determining the percentage of viral integration. METHODS Ninety two LSIL/HPV positive Thin Prep(TM) samples were initially tested for the E6 gene by the polymerase chain reaction (PCR) to identify the HPV-16 virus. To avoid false positive results, the specificity of the bands obtained from PCR was confirmed by Southern blot hybridisation with internal… CONTINUE READING
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