Study of vasodilator effects of papaverine, adenosine and related drugs in isolated cat cerebral arteries.


Papaverine, 1-methyl-3-isobutylxanthine (MIX), adenosine, cyclic-AMP (cAMP),dibutyryl-cAMP (db-cAMP) evoked concentration-dependent vasodilation in cat middle cerebral arteries precontracted with K+. The order of maximal vasodilator responses was: papaverine greater than MIX greater than adenosine = cAMP greater than or equal to db-cAMP, and with regard to… (More)


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