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Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix
- MedicineExpert opinion on drug safety
An updated assessment of the mutagenic and genotoxic effects of diazepam (DZ), one of the most commonly used benzodiazepines, on CL/P occurrence is presented.
EFFECTS OF DIAZEPAM AND MIDAZOLAM ADMINISTERED TO FEMALE WISTAR RATS DURING THE ORGANOGENIC PERIOD
Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs.
- Biology, MedicineToxicology and applied pharmacology
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE VETERINÁRIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS VETERINÁRIAS AVALIAÇÃO TOXICOLÓGICA DOS BENZODIAZEPÍNICOS DIAZEPAM E MALEATO DE MIDAZOLAM SOBRE O DESENVOLVIMENTO PRÉ-NATAL DE RATOS WISTAR
Can we use anxiolytics during pregnancy without anxiety?
- MedicineCanadian family physician Medecin de famille canadien
Evidence to date from cohort studies did not identify a notable association between use of benzodiazepines and increased risk of major malformations, including oral cleft, but data from case-control studies show a slightly increased risk.
Treatment of Anxiety During Pregnancy
- MedicineDrug safety
Nonpharmacological treatments such as cognitive behavioural therapy should be employed whenever possible for the treatment of anxiety disorders during pregnancy, and if medication is required pregnant women should be prescribed the lowest dosage for the minimum amount of time.
Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies
Pooled data from cohort studies showed no association between fetal exposure to benzodiazepines and the risk of major malformations or oral cleft, but on the basis of pooled data from case-control studies, however, there was a significant increased risk for major mal Formations or Oral cleft alone.
Embryotoxicity of 25 psychotropic drugs: a study using CHEST.
- MedicineReproductive toxicology
Teratogenic effect of cocaine and diazepam in CF1 mice.
Hydronephrosis and cryptorchidism were observed in the cocaine-treated groups, with the incidence of these malformations increasing significantly when diazepam was co-administered.