Study of the role of CCR5 in a mouse model of intranasal challenge with Yersinia pestis.

@article{Styer2007StudyOT,
  title={Study of the role of CCR5 in a mouse model of intranasal challenge with Yersinia pestis.},
  author={Katie L Styer and Eva M. Click and Gregory W Hopkins and Richard Frothingham and Alejandro Aballay},
  journal={Microbes and infection},
  year={2007},
  volume={9 9},
  pages={1135-8}
}
CCR5 is a chemokine receptor used by HIV-1 to enter cells and has recently been found to act as a pathogen associated molecule pattern receptor. Current positive selection for the high frequency of a CCR5-Delta32 allele in humans has been attributed to resistance to HIV, smallpox, and plague infections. Using an intranasal mouse model of Y. pestis infection, we have found that lack of CCR5 does not enhance host resistance to Y. pestis infection and that CCR5-mediated responses might have a… CONTINUE READING
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