Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol.

@article{Ginsburg1983StudyOT,
  title={Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol.},
  author={Robert Ginsburg and Michael R. Bristow and Margaret E. Billingham and Edward B. Stinson and John Speer Schroeder and Donald C. Harrison},
  journal={American heart journal},
  year={1983},
  volume={106 3},
  pages={
          535-40
        }
}
We evaluated the effects of isoproterenol in right ventricular papillary muscles derived from normal and failing isolated human hearts. Basal values for the peak force developed, rate of force development (dF/dt), and time to peak tension (TPT) were similar in both groups. Isoproterenol produced a significantly smaller (p less than 0.05) increase in peak force developed and dF/dt in failing papillary muscles. The half equivalent dose (ED50) of isoproterenol was fivefold higher in failing muscle… CONTINUE READING
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