Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor.


The phycotoxin palytoxin (PTX) binds to Na,K-ATPase, inhibiting its activity and converting the pump into a channel. These mechanisms are poorly understood. We examined the effect of PTX on membrane potential (E(m)), intracellular calcium concentration ([Ca2+]i) and intracellular pH (pH(i)) in primary cultures of cerebellar granule cells (CGC) and compared… (More)


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