Study of the mechanisms of cigarette smoke gas phase cytotoxicity.

  title={Study of the mechanisms of cigarette smoke gas phase cytotoxicity.},
  author={Christina Piperi and Aristea E Pouli and Nikolaos A Katerelos and Dimitris G. Hatzinikolaou and Anastasia J Stavridou and Miltiades C Psallidopoulos},
  journal={Anticancer research},
  volume={23 3A},
BACKGROUND The cytotoxicity of cigarette smoke (CS) in humans is well-documented, but the mechanism behind CS toxicity and carcinogenicity remains unknown. We are interested in the toxicological effects of CS gas phase and the biological mechanisms of its action. MATERIALS AND METHODS Gas phase CS cytotoxicity was measured by Wst-1 and LDH assays, in cultured cells. The mechanism of cell death was investigated by flow cytometric analysis using Annexin V and PI staining. Gas phase CS-induced… CONTINUE READING