Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.

@article{Quintana2006StudyOT,
  title={Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.},
  author={C Quintana and Salima Bellefqih and Johannes Yves Laval and Jean Luc Guerquin-Kern and Thomas D. Wu and Jes{\'u}s {\'A}vila and Isidro Ferrer and Roc{\'i}o Arranz and Cristina Pati{\~n}o},
  journal={Journal of structural biology},
  year={2006},
  volume={153 1},
  pages={42-54}
}
Previous studies of the structure of core nanocrystals of ferritin (Ft) in the brains of patients with Alzheimer's disease (AD) have shown differences in the mineral compound in comparison with physiological Ft. Both Ft cores have a polyphasic composition but whereas the major phase in physiological Ft is hexagonal ferric iron oxide (ferrihydrite), the major phases in brain AD Ft are two cubic mixed ferric-ferrous iron oxides (magnetite and wüstite). One of these (wüstite) is similar to what is… CONTINUE READING

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