Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor.

  title={Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor.},
  author={Genevi{\`e}ve Philippe and Laurent Nguyen and Luc Angenot and Michel Fr{\'e}d{\'e}rich and Gustave Moonen and Monique Tits and Jean-Michel Rigo},
  journal={European journal of pharmacology},
  volume={530 1-2},
In vivo Antimalarial and Antitrypanosomal Activity of Strychnogucine B, a Bisindole Alkaloid from Strychnos icaja.
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties and shows moderate in vitro antitrypanosomal activity but no in vivo activity in an acute Trypanosoma brucei model.
Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective.
Structures, synthetic approaches, metabolic transformations, and the diverse pharmacological actions of strychnine and its mono- and dimeric analogues are presented and discussed.
Alkaloids with antiprotozoal activity.
In vitro antiprotozoal, antimicrobial and antitumor activity of Pavetta crassipes K. Schum leaf extracts.
In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja that suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
Assessment of the in vitro and in vivo genotoxicity of extracts and indole monoterpene alkaloid from the roots of Galianthe thalictroides (Rubiaceae).
  • L. M. Fernandes, W. Garcez, Z. R. Guterres
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
Potential antimalarial activity of indole alkaloids.
Antimalarials from nature.
Combating malaria with plant molecules: a brief update.
There are several plant leads exhibiting antimalarial activity better than the existing drugs and a systematic evaluation of these plant based leads is the need of the time to develop safe, effective and affordable new antimalarials.
Ethnomedical Survey of Herbs for the Management of Malaria in Karnataka, India
Ethnobotany Research & Applications 11:289-298 (2013) Bangalore Nagendrappa Prakash and Payyappallimana Unnikrishnan.


Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A and B, which showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum.
New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots.
Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine and 18-hydroxy-sungucine, which showed a selective antiplasmodial activity.
The binding of strychnine and strychnine analogs to synaptic membranes of rat brainstem and spinal cord.
The results are in accord with the concept that the [3H]strychnine binding site detected in vitro is the site of pharmacological activity in vivo.
African Ethnobotany: Poisons and Drugs: Chemistry, Pharmacology, Toxicology
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A new HPLC method for the assay of alkaloids in Strychnos nux-vomica and Strychnos ignatii
A reversed-phase high-performance liquid chromatographic procedure was developed for the qualitative and quantitative analysis of the alkaloids in S. nux-vomica and S. ignatii.