Study of the interaction between rifapentine and isoniazid under acid conditions.

@article{Prasad2006StudyOT,
  title={Study of the interaction between rifapentine and isoniazid under acid conditions.},
  author={B. Prasad and H. Bhutani and S. Singh},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2006},
  volume={41 4},
  pages={
          1438-41
        }
}
A well-known problem of anti-tuberculosis fixed-dose combination (FDC) products containing rifampicin (R) and isoniazid (H) is the fall in bioavailability, in particular of R, when two or more drugs are present together. The same has been ascribed to hydrolysis of R to 3-formylrifamycin (3-RIF) under stomach acid conditions and reaction of the latter with H to form isonicotinyl hydrazone (HYD). The objective of present study was to explore whether the same reaction occurred when H was present… Expand
16 Citations
A novel inhalable form of rifapentine.
  • 33
Compatibility investigation for a new antituberculotic fixed dose combination with an adequate drug delivery
  • 3
...
1
2
...

References

SHOWING 1-8 OF 8 REFERENCES
Rifapentine: Its Role in the Treatment of Tuberculosis
  • 28
Behavior of Decomposition of Rifampicin in the Presence of Isoniazid in the pH Range 1–3
  • 51
Prospects for new antitubercular drugs.
  • 114