Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.

@article{Dashwood1996StudyOT,
  title={Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.},
  author={Roderick H Dashwood and Shoji Yamane and Rannveig Larsen},
  journal={Environmental and molecular mutagenesis},
  year={1996},
  volume={27 3},
  pages={211-8}
}
Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, forms molecular complexes with heterocyclic amine mutagens in vitro. In a previous study [Dashwood and Guo (1993): Environ Mol Mutagen, 22:164-171], we observed an inverse correlation between the binding constants of several mutagen-CHL complexes and the antimutagenic potency of CHL in the Salmonella assay. The present investigation utilized molecular mechanics methods of energy minimization and spectrophotometric titration to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Cancer prevention by natural compounds.

Drug metabolism and pharmacokinetics • 2004

Similar Papers

Loading similar papers…