Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs

@article{Bell2006StudyOT,
  title={Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs},
  author={R. Bell and R. Neiger and Y. McGrotty and I. Ramsey},
  journal={Veterinary Record},
  year={2006},
  volume={159},
  pages={277 - 281}
}
  • R. Bell, R. Neiger, +1 author I. Ramsey
  • Published 2006
  • Medicine
  • Veterinary Record
  • The effects of trilostane, a 3β-hydroxysteroid dehydrogenase inhibitor on basal cortisol concentrations and the results of acth stimulation tests in dogs with pituitary-dependent hyperadrenocorticism were investigated. In eight of nine dogs trilostane suppressed the concentration of cortisol below the lower limit of the reference range (<50 nmol/l) for a mean (sd) of 3·5 (2·3) hours during the day, but for no longer than 13 hours. In another 10 dogs, there was a clear difference between the… CONTINUE READING
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