Study of the effect of a glycosaminoglycan-peptide complex on the degradative enzyme activities in human osteoarthritic cartilage

Abstract

The in vitro collagenolytic and proteoglycanasic activity from human fibrillated osteoarthritic cartilage was determined using labelled proteoglycans and type II collagen as substrates. In vitro, a glycosaminoglycan-peptide complex (GP-C Rumalon®) induced a dose-dependent inhibition of both collagenolytic and proteoglycanasic activities while sodium… (More)
DOI: 10.1007/BF02114400

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