Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum
@article{Buchheit1985StudyOT, title={Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum}, author={Karl Heinz Buchheit and G{\"u}nter Engel and Ernst Mutschler and Brian P. Richardson}, journal={Naunyn-Schmiedeberg's Archives of Pharmacology}, year={1985}, volume={329}, pages={36-41} }
Summary1.The contractile effect of 5-HT in the isolated longitudinal ileal muscle of adult guinea-pigs was studied over a large concentration range.2.5-HT produced a biphasic concentration-response curve indicative of an interaction with at least two indenpendent populations of receptors. The concentrations which elicited half-maximal effects for the first and the second phases of the concentration-response curve were estimated as 1.5±1.2×10−8 mol/l and 1.3±0.4×10−6 mol/l respectively. The…
69 Citations
Characterization of 5-HT receptors mediating contraction and relaxation of the longitudinal muscle of guinea-pig distal colon in vitro
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Five receptors through which 5-hydroxytryptamine contracts and relaxes the longitudinal muscle of segments of guinea-pig distal colon, in vitro are characterized and it is concluded that 5-HT3, 5- HT4 and5-HT1-like receptors mediate contraction of the longitudinal Muscle of the distal Colon.
Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus
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5-methoxytryptamine may both inhibit (via 5-HT1 receptors) and facilitate (via5-HT4 receptors) the evoked release of acetylcholine from guinea-pig myenteric neurones and the facilitatory action is unmasked when the 5- HT1 receptor is blocked by methiothepine.
Cisplatin increases the release of 5-hydroxytryptamine (5-HT) from the isolated vascularly perfused small intestine of the guinea-pig: Involvement of 5-HT3 receptors
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Cisplatin, at concentrations which occur during anti-cancer therapy in humans and induce emesis, increases the release of 5-HT from the enterochromaffin cells of the small intestine of the guinea-pig.
Modulation by 5-HT3 and 5-HT4 receptors of the release of 5-hydroxytryptamine from the guinea-pig small intestine
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
The results suggest that enterochromaffin cells of the guinea-pig ileum do not contain 5-HT1 and5-HT2 receptors, but are endowed with 5- HT3 and 5-ht4 autoreceptors, which triggers a positive feedback mechanism leading to an increase of 5-hydroxytryptamine release.
5-HT1D and 5-HT4 Receptor Agonists Stimulate the Peristaltic Reflex in the Isolated Guinea Pig Ileum
- Biology, Medicine
- 1991
5-HT stimulates the peristaltic reflex in the isolated guinea pig ileum by activation of 5-HT4 and 5- HT1D receptors; other 5-ht receptor subtypes appear not to play a significant role in the modulation of this reflex.
5-Hydroxytryptamine affects rat migrating myoelectric complexes through different receptor subtypes: evidence from 5-hydroxytryptophan administration.
- Biology, ChemistryLife sciences
- 1990
Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro
- BiologyFront. Neurosci.
- 2014
Results indicate that luminal application of exogenous 5-HT, or increased release of endogenous mucosal5-HT above basal levels, acts to lower the threshold for propulsive contractions in the guinea-pig ileum via activation of 5- HT3 and 4-HT4 receptors and the release of tachykinins.
Effect of 5-hydroxytryptamine and its antagonists on colonic smooth muscle of the rabbit
- Biology, MedicineDigestive Diseases and Sciences
- 2005
5HT affects colonic contraction by a direct effect on muscle and indirectly through the enteric nerves and 5HT inhibits neurons responsible for the off-contraction in distal circular muscle without affecting the on-contracted muscle.
5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
It is concluded that 5-methoxytryptamine and 2-methyl-5-HT can be utilized as selective probes to discriminate the putative 5-HT4 receptor from the 5- HT3 receptor in guinea pig ileum.
Pharmacological evidence for interactions between 5-HT1A receptor agonists and subtypes of alpha 1-adrenoceptors on rabbit aorta.
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- 1993
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