Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation.

@article{Bignell2000StudyOT,
  title={Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation.},
  author={Dawn R. D. Bignell and Jonathan Warawa and Janice L. Strap and Keith F. Chater and Brenda K. Leskiw},
  journal={Microbiology},
  year={2000},
  volume={146 ( Pt 9)},
  pages={2161-73}
}
A cloned 2.5 kb DNA fragment that can restore antibiotic production and sporulation to a bldG mutant encodes a 113 aa protein showing similarity to a family of anti-anti-sigma factors from Bacillus and Staphylococcus; and the deduced product of a closely spaced downstream ORF, designated ORF3, shows similarity to cognate anti-sigma factors. The homologues in Bacillus regulate the activity of sporulation- and stress-response-specific sigma factors. However, there is no sigma factor gene near… CONTINUE READING