Study of the amidase signature group.

  title={Study of the amidase signature group.},
  author={H Chebrou and Fr{\'e}d{\'e}ric Bigey and Agbidinoukoun Arnaud and Pierre Galzy},
  journal={Biochimica et biophysica acta},
  volume={1298 2},
Computer methods for database search, multiple alignment and cluster analysis indicated significant homology between amino-acid sequences of 21 amidases or amidohydrolases (EC 3.5). All of them were found to be involved in the reduction of organic nitrogen compounds and ammonia production. A conserved motif was found which may be important in amide binding and in catalytic mechanisms. Homology studies between these amidases and some ureases, nitrilases and acyl-transferases or enzymes with… CONTINUE READING

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