• Corpus ID: 212496479

Study of the Possible Modulatory Effect of Resveratrol and Coenzyme Q10 on MPTP-Induced Parkinsonism in Mice

@inproceedings{Rahman2012StudyOT,
  title={Study of the Possible Modulatory Effect of Resveratrol and Coenzyme Q10 on MPTP-Induced Parkinsonism in Mice},
  author={Mohamed Abdel Rahman and Ayman Elsheikh},
  year={2012}
}
Background: Parkinson's disease is a motor system disease caused by factors that compromise survival of the dopaminergic neurons in the substantia nigra. The mechanisms of degeneration of these neurons include mitochondrial dysfunction, oxidative stress and neuroinflammation. CoQ10 is a fat-soluble vitamin found in the inner mitochondrial membrane and is involved in the electron transport chain that supplies energy to vital organs. Resveratrol is a natural polyphenolic compound found in grapes… 
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References

SHOWING 1-10 OF 58 REFERENCES
Combination therapy with Coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases
TLDR
The findings suggest that combination therapy using CoQ10 and creatine may be useful in the treatment of neurodegenerative diseases such as Parkinson’s disease and HD.
Bioenergetic approaches for neuroprotection in Parkinson's disease
  • M. Beal
  • Biology
    Annals of neurology
  • 2003
TLDR
Creatine has been shown to be effective in several animal models of neurodegenerative diseases and currently is being evaluated in early stage trials in PD, and coenzyme Q10 is also effective in animal models and has shown promising effects both in clinical trials of PD as well as in clinical Trials in Huntington's disease and Friedreich's ataxia.
Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases
TLDR
The goal here is to provide a better understanding of the mode of action of resveratrol and its possible use as a potential therapeutic agent to ameliorate stroke damage as well as other age-related neurodegenerative disorders.
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease
TLDR
Drosophila as a valuable model for preclinical testing of drugs with therapeutic potential for neurodegenerative diseases is further validates, and drugs combining antioxidant and anti-inflammatory properties as strong therapeutic candidates for mechanism-based PD treatment are implicate.
Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions
TLDR
It is suggested that resveratrol exerts neuroprotection against LPS-induced dopaminergic neurodegeneration, and NADPH oxidase may be a major player in resver atrol-mediated neuroprotection.
Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro.
  • D. Lee, Cuk-Seong Kim, Yong J. Lee
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice
Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders.
Oxidative stress and the pathogenesis of Parkinson's disease
TLDR
Selegiline may act through a mechanism unrelated to MAO-B to increase neurotrophic factor activity and upregulate molecules such as glutathione, SOD, catalase, and BCL-2 protein, which protect against oxidant stress and apoptosis.
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