Study of the Determinants of Vitamin D Status in Pediatric Patients With Osteogenesis Imperfecta

@article{Zambrano2016StudyOT,
  title={Study of the Determinants of Vitamin D Status in Pediatric Patients With Osteogenesis Imperfecta},
  author={Marina Bauer Zambrano and Evelise Brizola and Bruna Pinheiro and A.P. Vanz and Elza Daniel de Mello and T{\^e}mis Maria F{\'e}lix},
  journal={Journal of the American College of Nutrition},
  year={2016},
  volume={35},
  pages={339 - 345}
}
Objective: Vitamin D is essential to the development and maintenance of the skeleton, especially for children with bone disorders such as osteogenesis imperfecta (OI). We evaluated serum 25-hydroxyvitamin D (25-OHD) levels to assess the relationship between determinants of vitamin D status in pediatric patients with OI. Methods: This cross-sectional study evaluated sex, age, weight, height, body mass index, OI type, sunscreen use, season of assessment, sun exposure, vitamin D and calcium… 
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It is shown that vitamin D deficiency is prevalent amongst OI children in southern Iran, and more than half of the OIChildren had low bone mass for chronological age in lumbar area, despite receiving bisphosphonate therapy.
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An increase in calcium intake is observed in patients with OI after a nutritional intervention, demonstrating the importance of nutrition therapy as part of a multidisciplinary treatment approach for bone health.
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Increasing awareness of bone health issues in children will improve their recognition and treatment and most importantly prevention of pediatric bone health diseases.
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Newer medications with anti-resorptive and bone anabolic action are being investigated in an attempt to improve on the efficacy of bisphosphonates but the safety and efficacy of these new approaches in children with OI is not yet established.
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TLDR
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TLDR
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TLDR
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TLDR
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