Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice

@article{Silva2012StudyOT,
  title={Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice},
  author={Andr{\'e} F.C da Silva and J. Neves and J. I. Irm{\~a}o and V. Costa and V. M. Souza and P. L. de Medeiros and E. D. da Silva and M. D. de Lima and I. Pitta and M. Albuquerque and S. Galdino},
  journal={The Scientific World Journal},
  year={2012},
  volume={2012}
}
Previous studies conducted with the imidazolidinic derivative 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one (LPSF-PT05) show outstanding activity against adult Schistosoma mansoni worms in vitro. In the first phase of this study, S. mansoni-infected mice were treated, orally, with 100 mg/Kg of the LPSF-PT05 in three formulations: Tween 80 and saline solution, oil/water (70 : 30) emulsion, and solid dispersion with polyethylene glycol (PEG). In the second phase, three other doses of… Expand
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