Study of tauopathies by comparing Drosophila and human tau in Drosophila

@article{Chen2007StudyOT,
  title={Study of tauopathies by comparing Drosophila and human tau in Drosophila},
  author={Xinping Chen and Yan Li and Junbo Huang and Dawei Cao and Guoying Yang and Weijie Liu and Huimin Lu and Aike Guo},
  journal={Cell and Tissue Research},
  year={2007},
  volume={329},
  pages={169-178}
}
The microtubule-binding protein tau has been investigated for its contribution to various neurodegenerative disorders. However, the findings from transgenic studies, using the same tau transgene, vary widely among different laboratories. Here, we have investigated the potential mechanisms underlying tauopathies by comparing Drosophila (d-tau) and human (h-tau) tau in a Drosophila model. Overexpression of a single copy of either tau isoform in the retina results in a similar rough eye phenotype… CONTINUE READING

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Drosophila protocols. Cold Spring Harbor Laboratory, Cold Spring

  • W Sullivan, M Ashburner, RS Hawley
  • 2000
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