Study of potential in vitro and in vivo genotoxicity in hepatocytes of quinolone antibiotics.

@article{Mcqueen1991StudyOP,
  title={Study of potential in vitro and in vivo genotoxicity in hepatocytes of quinolone antibiotics.},
  author={Charlene A. Mcqueen and B M Way and S M Queener and Gerhard Schlüter and G. M. Williams},
  journal={Toxicology and applied pharmacology},
  year={1991},
  volume={111 2},
  pages={
          255-62
        }
}
Hepatocyte Culture as an In Vitro Model for Evaluating the Hepatotoxicity of Food-Borne Toxicants and Microbial Pathogens: A Review
  • S. Sahu
  • Biology, Medicine
    Toxicology mechanisms and methods
  • 2003
TLDR
Hepatocytes, especially human hepatocytes, are used for preclinical drug evaluation and screening as well as for studies of drug metabolism, toxicity, interactions, and structure-activity relationships, and are suitable for use in qualitative hazard assessment.
Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin
TLDR
It is indicated that OFX has cytotoxic, cytostatic and genotoxic potential especially at higher concentrations on human peripheral blood lymphocyte cultures under the experimental conditions.
Effects of new quinolone antibacterial agents on mammalian chromosomes.
  • H. Shimada, S. Itoh
  • Biology, Chemistry
    Journal of toxicology and environmental health
  • 1996
TLDR
Clastogenic effects of several new quinolones were studied cytogenetically using Chinese hamster lung cells (CHL) and the mouse micronucleus test and the lack of concordance between in vitro and in vivo assays could reflect the differences in the tissue levels of the drugs and the in vitro conditions.
Antimutagenesis of vitamin AD3E mixture to mutations induced by flouroquinolone drug ciprofloxacin on mice
TLDR
Investigation of antimutagenic effect of vitamin AD3E mixture against the genetic damage induced by ciprofloxacin (CFX) drug showed that vitaminAD3E inhibit the DNA damageinduced by CFX in dose and time dependent in compared to the CFX alone.
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test.
Effect of quinolone antibiotics on hepatic growth and protein synthesis following partial hepatectomy in rats
TLDR
The findings suggest that the quinolone antibiotics are unlikely to have an adverse effect on hepatic recovery following surgical resection of the liver and are safe to use in that setting.
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The calculated apparent Kd values of these analogues correlate well with their Ki values, providing strong evidence that the binding affinity of the drug to DNA determines biological potency.
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