Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats.

@article{Sodhi1997StudyOO,
  title={Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats.},
  author={Chhinder Pal Sodhi and Suresh Vir Singh Rana and Surya Kant Mehta and Kim Vaiphei and Saleh Attari},
  journal={Drug and chemical toxicology},
  year={1997},
  volume={20 3},
  pages={
          255-69
        }
}
The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (microvesicular fat deposition) with mild portal triaditis. The glutathione and related thiols were significantly decreased in both blood and liver tissues with combination of INH and… CONTINUE READING
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