Study of ocular pharmacokinetics of in situ gel system for S(-)-satropane evaluated by microdialysis.

@article{Fu2008StudyOO,
  title={Study of ocular pharmacokinetics of in situ gel system for S(-)-satropane evaluated by microdialysis.},
  author={Jun Fu and Xuemei Feng and Haihong Yuan and Liming Yan and Xiaodong Kuang and Zheng Xia and Xiaoling Gao and Cheng Yi Yu and Yang Lu and HongZhuan Chen},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2008},
  volume={48 3},
  pages={840-3}
}
S(-)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(-)-satropane, the microdialysis method was employed. The concentration of S(-)-satropane in dialysates was measured by using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Unlike the common solution prepared in normal saline, in which the level of S(-)-satropane in aqueous humor increased rapidly… CONTINUE READING

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