Study of neuropathologic changes in the striatum following 4, 8 and 12 months of treatment with fluphenazine in rats

@article{Jeste1992StudyON,
  title={Study of neuropathologic changes in the striatum following 4, 8 and 12 months of treatment with fluphenazine in rats},
  author={Dilip V. Jeste and James B. Lohr and Michael Manley},
  journal={Psychopharmacology},
  year={1992},
  volume={106},
  pages={154-160}
}
Persistent tardive dyskinesia is a serious side effect of long-term treatment with neuroleptics. Although striatal pathologic changes are believed to underlie this potentially irreversible iatrogenic syndrome, the nature of the neuroleptic-induced neuropathology is unclear. In the present study, we treated rats with either vehicle or fluphenazine decanoate… CONTINUE READING