Study of matrix additives for sensitive analysis of lipid A by matrix-assisted laser desorption ionization mass spectrometry.

@article{Zhou2010StudyOM,
  title={Study of matrix additives for sensitive analysis of lipid A by matrix-assisted laser desorption ionization mass spectrometry.},
  author={Ping Zhou and Eleonora Altman and Malcolm B. Perry and Jianjun Li},
  journal={Applied and environmental microbiology},
  year={2010},
  volume={76 11},
  pages={
          3437-43
        }
}
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely used for structural characterization of bacterial endotoxins (lipid A). However, the mass spectrometric behavior of the lipid A molecule is highly dependent on the matrix. Furthermore, this dependence is strongly linked to phosphorylation patterns. Using lipid A from Escherichia coli O116 as a model system, we have investigated the effects of different matrices and comatrix compounds on… CONTINUE READING

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