Study of in vivo and in vitro resting vasodilator nitric oxide tone in normotensive and genetically hypertensive rats.

@article{GilLongo1996StudyOI,
  title={Study of in vivo and in vitro resting vasodilator nitric oxide tone in normotensive and genetically hypertensive rats.},
  author={Jos{\'e} Gil-Longo and D Fern{\'a}ndez-Grandal and Manel {\'A}lvarez and M Sieira and Francisco Orallo},
  journal={European journal of pharmacology},
  year={1996},
  volume={310 2-3},
  pages={
          175-83
        }
}
The effects of NG-nitro-L-arginine (L-NNA) on mean arterial pressure and the effects of both L-NNA and methylene blue on isolated aorta tone, were studied in order to elucidate potential alterations in vasodilator resting nitric oxide (NO) tone in genetic hypertension. L-NNA produced a significantly greater increase of mean arterial pressure in spontaneously hypertensive rats (SHR) than in Wistar Kyoto (WKY) rats; in both cases, L-arginine completely inhibited the L-NNA hypertensive effect… CONTINUE READING

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