Study of in vitro drug sensitivity on a newly established cell line from a primary bronchial epidermoid carcinoma of human origin (NSCLCN6).

@article{Roussakis1991StudyOI,
  title={Study of in vitro drug sensitivity on a newly established cell line from a primary bronchial epidermoid carcinoma of human origin (NSCLCN6).},
  author={Christos Roussakis and Catherine Gratas and A F Audouin and J Le Boterff and C Dabouis and Marc François Jean Andr{\'e} and E Moyon and N. H. Vo and Gilbert Pradal and Jean François Verbist},
  journal={Anticancer research},
  year={1991},
  volume={11 6},
  pages={2239-44}
}
We studied a cell line established from a primary non-small-cell lung cancer (non-SCLC) of human origin and characterized by midly differentiated epidermoid carcinoma, a human karyotype and keratin expression. Doubling time was about 48 h in vitro and 12 days when transplanted into nude mice. In vitro, this cell line was mainly sensitive to dactinomycin and mitotic poisons such as Vinca alkaloids. Most chemotherapeutic drugs proved ineffective. Our findings are comparable to previous results in… CONTINUE READING