Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog.

@article{Patak1979StudyOF,
  title={Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog.},
  author={R V Patak and S Z Fadem and Meyer D. Lifschitz and Jay H. Stein},
  journal={Kidney international},
  year={1979},
  volume={15 3},
  pages={227-37}
}
Previous studies have demonstrated that the fall in inulin clearance which occurs 3 hours after the intrarenal administration of norepinephrine can be markedly attenuated by the prior administration of intrarenal prostaglandin E2 (PGE). Since in the previous studies PGE led to a marked increase in both renal blood flow and solute excretion, we designed the present series of experiments to investigate whether an increase in renal blood flow, solute excretion, or other factors were responsible… CONTINUE READING

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