Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments

@article{Bajda2015StudyOE,
  title={Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments},
  author={Marek Bajda and Sławomir Filipek},
  journal={Computational biology and chemistry},
  year={2015},
  volume={56},
  pages={13-8}
}
β-amyloid aggregation and formation of senile plaques is one of the hallmarks of Alzheimer's disease (AD). It leads to degeneration of neurons and decline of cognitive functions. The most aggregative and toxic form of β-amyloid is Aβ1-42 but in experiments, the shorter forms able to form aggregates are also used. The early stages of amyloid formation are of special interest due to the influence of this peptide on progression of AD. Here, we employed nine helices of undecapeptide Aβ13-23 and… CONTINUE READING

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