Study of dopamine turnover by monitoring the decline of dopamine metabolites in rat CSF after alpha-methyl-p-tyrosine.

@article{Mignot1985StudyOD,
  title={Study of dopamine turnover by monitoring the decline of dopamine metabolites in rat CSF after alpha-methyl-p-tyrosine.},
  author={Emmanuel Mignot and Dominique Laude},
  journal={Journal of neurochemistry},
  year={1985},
  volume={45 5},
  pages={1527-33}
}
CSF was continuously withdrawn from the third ventricle of anesthetized rats. CSF 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid concentrations were determined every 15 min by liquid chromatography coupled with electrochemical detection. Acute tyrosine hydroxylase inhibition [with alpha-methyl-p-tyrosine (alpha-MPT)] induced an exponential decline in levels of DOPAC and HVA in CSF. The decline in DOPAC and HVA concentrations was identical in CSF… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 2 Excerpts

Similar Papers

Loading similar papers…