Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro.

@article{Horvthov2006StudyOC,
  title={Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro.},
  author={Eva Horv{\'a}thov{\'a} and Monika {\vS}r{\'a}mkov{\'a} and Juraj L{\'a}baj and Darina Slameňov{\'a}},
  journal={Neuro endocrinology letters},
  year={2006},
  volume={27 Suppl 2},
  pages={44-7}
}
OBJECTIVES To investigate cytotoxic, genotoxic and DNA-protective effects of carvacrol and thymol on human hepatoma HepG2 and colonic Caco-2 cells cultured in vitro. METHODS AND RESULTS Cytotoxicity testing was performed by the trypan blue exclusion technique. Level of DNA lesions induced in human cells with carvacrol, thymol or their combinations with hydrogen peroxide (H(2)O(2)) were measured by alkaline single cell gel electrophoresis (comet assay). The trypan blue exclusion technique… CONTINUE READING