Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.

@article{Leira2001StudyOC,
  title={Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.},
  author={F. Leira and C. Alvarez and J. Vieites and M. Vieytes and L. Botana},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2001},
  volume={15 4-5},
  pages={
          277-82
        }
}
  • F. Leira, C. Alvarez, +2 authors L. Botana
  • Published 2001
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
The diarrhogenic activity of the marine toxin okadaic acid (OA) has been associated to its actin-disrupting effect, which could reflect the loosening of tight junctions in vivo. In this report, we present results obtained using a fluorimetric microplate assay for quantitative measurements of OA-induced changes on F-actin pools in BE(2)-M17 cells. The proposed method shows important advantages over classical methods in terms of rapidity, sensitivity (less than 5000 cells per well) and… Expand
Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells.
Effect of okadaic acid on integrins and structural proteins in BE(2)-M17 cells
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