Study of critical points of drugs with different solubilities in hydrophilic matrices.

@article{Fuertes2010StudyOC,
  title={Study of critical points of drugs with different solubilities in hydrophilic matrices.},
  author={Inmaculada Fuertes and Isidoro Caraballo and Antonia Miranda and M{\'o}nica Mill{\'a}n},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={383 1-2},
  pages={138-46}
}
Hydrophilic matrices are one of the most popular controlled release systems in the world. It is well known that drug solubility increases the osmotic stress in hydrophilic matrices, resulting in higher swelling through the creation of microcavities and influencing the release rate. Drug solubility also affects the drug release mechanism, favouring the diffusion against the erosion mechanism. Nevertheless it has not been studied whether this can modify the critical points of the hydrophilic… CONTINUE READING