Corpus ID: 235731993

Study of conduction, block and reflection at the excitable tissues boundary in terms of the interval model of action potential

@inproceedings{Kovalchuk2021StudyOC,
  title={Study of conduction, block and reflection at the excitable tissues boundary in terms of the interval model of action potential},
  author={Sergii Kovalchuk},
  year={2021}
}
Some mechanisms of cardiac arrhythmias can be presented as a composition of elementary acts of block and reflection on the contacts of homogeneous areas of the conducting tissue. For study this phenomena we use an axiomatic one-dimensional model of interaction of cells of excitable tissue. The model has four functional parameters that determine the functional states durations of the cell.. We show that the cells of a homogeneous excitable tissue, depending on the ratio of the durations of the… Expand

Figures from this paper

References

SHOWING 1-10 OF 25 REFERENCES
A Model Study of the Effects of the Discrete Cellular Structure on Electrical Propagation in Cardiac Tissue
TLDR
The effects of the discrete cellular structure on propagation of electrical excitation in cardiac muscle were studied in a one-dimensional fiber model containing a periodic intercalated disk structure and results demonstrate the discontinuous nature of propagation and the importance of the structure in arrhythmogenesis. Expand
Unidirectional block and reentry of cardiac excitation: a model study.
TLDR
Inhomogeneity along the reentry pathway in refractory period, in membrane excitability, in fiber cross-sectional area, or in gap junction resistance provided conditions necessary for unidirectional block. Expand
Basic mechanisms of cardiac impulse propagation and associated arrhythmias.
TLDR
This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart. Expand
An electric field mechanism for transmission of excitation between myocardial cells.
TLDR
A long-standing dogma in basic electrophysiology of the heart has been that the atrial and ventricular myocardial cells are interconnected by low-resistance pathways mediated by gap-junction connexon channels, which has become ingrained in most textbooks and advanced reference books dealing with the heart. Expand
Role of gap junctions in the propagation of the cardiac action potential.
  • S. Rohr
  • Chemistry, Medicine
  • Cardiovascular research
  • 2004
TLDR
It has been shown that fibroblasts establish successful conduction between sheets of cardiomyocytes over distances as long as 300 microm, which might not only explain electrical synchronization of heart transplants but might be of importance for cardiac diseases involving fibrosis. Expand
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
TLDR
Simulation of the membrane action potential of the mammalian ventricular cell shows the importance of the slow recovery of INa in determining the response of the cell and relates these phenomena to the underlying ionic channel kinetics. Expand
Some Characteristics of Ventricular Echoes
TLDR
It was concluded that a self-sustained repetitive circuit may be possible when the round-trip conduction time exceeds the refractory period of the limiting tissue in the node. Expand
Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
  • G. Tse, J. M. Yeo
  • Medicine
  • International journal of cardiology. Heart & vasculature
  • 2015
TLDR
Experimental results are synthesized to illustrate molecular mechanisms of how abnormalities in these proteins contribute to conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes. Expand
Heart Rhythm Insights Into Structural Remodeling in Atrial Tissue: Timed Automata Approach
TLDR
Modulation in the impairment of the impulse transmission between cells reveals qualitatively the abnormally high heart rate variability observed in patients living long after HTX. Expand
Mechanisms of cardiac conduction: a history of revisions.
TLDR
A brief review of how the conceptual understanding of conduction has evolved over the last century is provided and recent, potentially paradigm-shifting developments are highlighted. Expand
...
1
2
3
...