Study of claudin function by RNA interference.

  title={Study of claudin function by RNA interference.},
  author={Jianghui Hou and Antonio S Gomes and David L. Paul and Daniel A. Goodenough},
  journal={The Journal of biological chemistry},
  volume={281 47},
Claudins are tight junction proteins that play a key selectivity role in the paracellular conductance of ions. Numerous studies of claudin function have been carried out using the overexpression strategy to add new claudin channels to an existing paracellular protein background. Here, we report the systematic knockdown of endogenous claudin gene expression in Madin-Darby canine kidney (MDCK) cells and in LLC-PK1 cells using small interfering RNA against claudins 1-4 and 7. In MDCK cells… CONTINUE READING
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