Study of bioavailability of hydrocortisone acetate in rectal administration of the foamy preparation to rabbits


1. Comparative study of the pharmacokinetics of HCA from a suspension and foam during rectal and intramuscular administration to rabbits showed that only the foam preparation introduced rectally ensures continuous and prolonged absorption of HCA from the foam for 5–6 h into the systemic blood flow and a considerable accumulation of HCA in the rectal tissue… (More)
DOI: 10.1007/BF00780575


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