[Study of antisense oligodeoxynucleotide in reversing multidrug resistance and inducing apoptosis of tumor cells].

Abstract

OBJECTIVE T o explore an approach to the reversal of multidrug resistance(MDR) of tumor cells. METHODS Antisense oligodeoxynucleotide (mdr-1-AS PS-ODN) was used. RESULTS A large amount of DNA fragments was found in mdr-1-AS PS-ODN treated K562/ADM cells and almost all the mdr-1+ K562/ADM cells underwent apoptosis. CONCLUSION mdr-1-AS PS-ODN could… (More)

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@article{Zhang1997StudyOA, title={[Study of antisense oligodeoxynucleotide in reversing multidrug resistance and inducing apoptosis of tumor cells].}, author={Fa Zhang and Y Lin and Y Jiang and X. Zhang}, journal={Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi}, year={1997}, volume={18 12}, pages={627-9} }