Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine, blood plasma, and liver extracts.

@article{Wang2006StudyOA,
  title={Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine, blood plasma, and liver extracts.},
  author={Quanjun Wang and Ying Jiang and Chunqi Wu and Jianyu Zhao and Shouzhong Yu and Benli Yuan and Xianzhong Yan and Mingyang Liao},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={215 1},
  pages={71-82}
}
Antiangiogenic compound has been believed to be an ideal drug in the current cancer biological therapy, but the angiogenesis inhibitors suffer setback for unknown toxicity now. A novel synthetic indolin-s-ketone small molecular compound, 3Z-3-[((1)H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one (Z24) can inhibit angiogenesis in new blood vessels. The hepatotoxicity effects of Z24 oral administration (dosed at 60, 130 and 200 mg/kg) have been investigated in female Wistar… CONTINUE READING
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