• Corpus ID: 54194013

Study of Some Lymphoproliferative Clonal Markers Following Renal Transplantation

  title={Study of Some Lymphoproliferative Clonal Markers Following Renal Transplantation},
  author={Elham Ragab Abdel-Samea and Ahmad Shawki Mohammed and Farha A. El-Chennawi},
Post-renal transplant lymphoproliferative disorders (PTLDs) is a well known category among all the other lymphoproliferative disorders. The cause of this complication is mainly due to long term immunosuppression, and infection particularly by Epstein-Barr virus. The aim of this work is the early recognition of clonal changes for early therapeutic intervention as most of these changes are polyclonal. Yet the transition to oligo - and subsequent monoclonal is important for follow up with the… 

Figures and Tables from this paper


Posttransplant lymphoproliferative disease: Pathogenesis, monitoring, and therapy
  • R. Ambinder
  • Medicine, Biology
    Current oncology reports
  • 2003
The spectrum of transplant-related lymphoproliferative diseases is expanding to include a variety of neoplasias that typically occur late after transplant including Epstein-Barr virus (EBV)-negative
Posttransplant T-cell lymphoproliferative disorders--an aggressive, late complication of solid-organ transplantation.
A clinically aggressive T-PTLD may be a late complication of solid-organ transplantation and does not appear to be related to EBV,HTLV-1, HTLV-2, or HHV-8 infection.
Flow cytometric evaluation of posttransplant B-cell lymphoproliferative disorders.
Both polymorphic and monomorphic PTLDs show a higher incidence of lack of CD20 and surface immunoglobulin light-chain expression, which may have therapeutic implications, since anti-CD20 antibody has increasingly become an important modality in the treatment of B-cell lymphoproliferative disorders, including posttransplant disorders.
Clinical and pathological features of posttransplant lymphoproliferative disorders: influence on survival and response to treatment.
  • R. Hauke, B. Smir, J. Armitage
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2001
Patients with PTLD can achieve long-term survival and surgery can play an important role in selected patients, according to retrospective review of 32 patients.
Identifying the patient at risk for post‐transplant lymphoproliferative disorder
  • S. Cockfield
  • Medicine
    Transplant infectious disease : an official journal of the Transplantation Society
  • 2001
Opportunities exist to target those populations at highest risk for the development of PTLD for aggressive monitoring and pre‐emptive or prophylactic therapy, and it is hoped that implementation of such strategies will render early PTLD a preventable complication of transplantation.
Dissociation of Depletional Induction and Posttransplant Lymphoproliferative Disease in Kidney Recipients Treated With Alemtuzumab
  • A. Kirk, W. Cherikh, H. Kauffman
  • Biology, Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2007
Depletional induction is not an independent risk factor for posttransplant lymphoproliferative disease and maintenance drug selection or perhaps the balance between B‐ and T‐cell depletion may be more relevant determinants of PTLD risk.
Hodgkin's lymphoma after post‐transplant lymphoproliferative disease in a renal transplant recipient
Abstract:  Lymphoid malignancies such as post‐transplant lymphoproliferative disease (PTLD) are a major complication of solid organ transplantation. Hodgkin's lymphoma (HL) is not part of the typical
Pretransplant Donor-Specific Antibodies in Cytotoxic Negative Crossmatch Kidney Transplants: Are They Relevant?
Data show that in the context of a CDC-negative crossmatch, the presence of D0 DSA has little impact on any early graft parameters, however, DSA are associated with poorer longer-term graft outcomes in kidney transplantation.
Lymphomas After Solid Organ Transplantation: A Collaborative Transplant Study Report
  • G. Opelz, B. Döhler
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2004
The continuing risk for lymphoma with time post‐transplantation, the contribution of immunosuppression to increased risk, and continuing poor outcomes in patients with post-transplant lymphoma are highlighted.
Weak Humoral Posttransplant Alloresponse after a Well–HLA-Matched Cadaveric Kidney Transplantation
In immunologically low-risk kidney-graft recipients, positive T-cell IgM FCXM at transplantation was found to be a risk factor for rejection episodes and cytomegalovirus infections.