Study of Polymorphs of Progesterone by Novel Melt Sonocrystallization Technique: A Technical Note

  title={Study of Polymorphs of Progesterone by Novel Melt Sonocrystallization Technique: A Technical Note},
  author={Rahul Tripathi and Shailesh V. Biradar and Brahmeshwar Mishra and Anant Paradkar},
  journal={AAPS PharmSciTech},
A large number of pharmaceuticals exhibit polymorphism; 23% steroids, 60% sulfonamides, and 70% of barbiturates have shown this property. In this study, we have investigated and compared a new technique termed as melt sonocrystallization (MSC) with melt and sonocrystallization (SC) for induction of polymorphism in progesterone (PRG). Polymorphs were characterized by DSC, XRD, FT-IR, and FT Raman spectroscopy. Melt sonocrystallized progesterone (MSC-PRG) contained both the polymorphs, more… CONTINUE READING


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