Study of P450 function using gene knockout and transgenic mice.

@article{Gonzalez2003StudyOP,
  title={Study of P450 function using gene knockout and transgenic mice.},
  author={Frank J. Gonzalez and Shioko Kimura},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={409 1},
  pages={153-8}
}
The xenobiotic-metabolizing P450s have been extensively studied for their ability to metabolize endogenous and exogenous chemicals. The latter include drugs and dietary and environmentally derived toxicants and carcinogens. These enzymes also metabolize endogenous steroids and fatty acids. P450s are thought to be required for efficient removal of most… CONTINUE READING