Study of Effects of Antiglaucoma Eye Drops on N-Methyl-d-Aspartate-Induced Retinal Damage

  title={Study of Effects of Antiglaucoma Eye Drops on N-Methyl-d-Aspartate-Induced Retinal Damage},
  author={Tomomi Metoki and Hiroshi Ohguro and Ikuyo Ohguro and Kazuhisa Mamiya and Tadashi Ito and Mitsuru Nakazawa},
  journal={Japanese Journal of Ophthalmology},
To study the effects of antiglaucoma eye drops on N-methyl-d-aspartate (NMDA)-induced retinal damage. Several antiglaucoma eye drops, β-blockers, α/β-blockers, an α1-blocker, an α2-agonist, and a prostaglandin derivative, were topically administrated to NMDA-treated rat eyes daily for 2 weeks, and the retinal thickness, the number of retrograde-labeled retinal ganglion cells (RGCs), and the results of a cDNA microarray analysis were studied. Intravitreal administration of NMDA caused a… CONTINUE READING
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