Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin.

@article{Ricard2012StudyOC,
  title={Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin.},
  author={Anne Sophie Ricard and Catherine Pain and Alexia Daubos and K Ezzedine and Isabelle Lamrissi-Garcia and Alice Bibeyran and V{\'e}ronique Guyonnet-Dup{\'e}rat and Alain Taieb and Muriel Cario-Andre},
  journal={Experimental dermatology},
  year={2012},
  volume={21 6},
  pages={411-6}
}
We have hypothesised that melanocytes disappear in vitiligo because they are weakly attached to the epidermal basal membrane (melanocytorrhagy). In the epidermis, attachment of melanocytes to collagen IV is mediated through DDR1, which is under the control of CCN3. DDR1 genetic variants have been associated with vitiligo in patients of different ethnic origin. In vitro studies have shown that inhibition of CCN3 induces the detachment of melanocytes. We have studied in parallel the expression of… CONTINUE READING

References

Publications referenced by this paper.

Oxidative stress

M Picardo, M L.Dell’Anna
Vitiligo. Berlin Heidelberg: Springer-Verlag, • 2010

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