Study design and the drug development process.


blood pressure monitoring as the main outcomes,3 whereas others have used the change in 24-hour mean blood pressure.4 We decided to use the change in the 24-hour mean blood pressure, although the sample size calculated for our study allowed the study to be powered to detect change in the 24-hour SBP in both ITT and per-protocol analyses as well. Therefore… (More)
DOI: 10.1001/jama.2014.3826