Studies with wortmannin and cytochalasins suggest a pivotal role of phosphatidylinositols in the regulation of tight junction integrity.

Abstract

Wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase (P13K), was found to give a dose and time-dependent, bimodal effect-initial increase, followed by decrease on the tight junction integrity of MDCK-1 monolayers, as assessed by electrical resistance measurement of the epithelia. Moreover, dihydrocytochalasin B inhibited the wortmannin-induced… (More)

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