Studies with Thiohexital, an Anesthetic Barbiturate Metabolized with Unusual Rapidity in Man

L. C. Mark; J. M. Perel; L. Brand; P. Dayton

DOI:10.1097/00000542-196811000-00013

Corpus ID: 38183603

Studies with Thiohexital, an Anesthetic Barbiturate Metabolized with Unusual Rapidity in Man

@article{Mark1968StudiesWT,
  title={Studies with Thiohexital, an Anesthetic Barbiturate Metabolized with Unusual Rapidity in Man},
  author={L. C. Mark and J. M. Perel and L. Brand and P. Dayton},
  journal={Anesthesiology},
  year={1968},
  volume={29},
  pages={1159–1166}
}

L. C. Mark, J. M. Perel, +1 author P. Dayton

Published 1968

Medicine

Anesthesiology

Thiohexital, a des-methyl-thio analog of methohexital, has been found to be the most rapidly metabolized intravenous barbiturate yet studied in man. It is more highly bound to plasma proteins than are thiopental and methohexital. The uptake by human adipose tissue, studied in vivo by means of serial biopsies, was considerably less than the uptake of thiopental. An analysis which correlates clinical features of the drug with physicochemical and metabolic factors is presented. It appears that a… CONTINUE READING

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